Showing posts with label blood testosterone. Show all posts

The Use of Testosterone Gel

Testosterone Gel

Thousands of middle-aged men use testosterone gels to increase blood testosterone levels. Hormone replacement therapy assists men in maintaining muscle and bone mass, improves mood, enhances metabolic health, prevents depression, and boosts sexual performance. Gels are often better than injections because they provide a more steady level of blood testosterone.

A study from the Center for Sexual Function/Endocrinology in Massachusetts, showed that applying testosterone gel to the arms and shoulders stimulated the production of higher blood testosterone levels than rubbing the gel on the chest, abdomen, or legs. The study examined middle-aged men with low blood testosterone levels (less than 300 nanograms per 100 ml). Applying the gel to the arms and shoulders increased testosterone above 500 mg, which is within the usual range for adult men. Testosterone levels were 20 percent less after rubbing the gel on other places. This is extremely significant information for men who use supplemental testosterone gels or creams.
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IGF-1 Activates Androgen Receptor Activity

IGF-1

Testosterone is a highly anabolic hormone that acts by binding with androgen receptors. This signals the cell nucleus to augment the synthesis of new proteins. Until recently, scientists and physicians looked at the role of testosterone in muscle metabolism at a very superficial level. They suppose that a normal blood testosterone level meant that the system was functioning normally and even optimally. Advances in cellular biochemistry showed that the system is much more complicated.

Activation of specific genes and hormone receptor sites are more imperative than circulating levels of hormones and chemical growth factors. Besides, hormones such as testosterone, human growth hormone, and IGF-I must work together to make the optimal effect. A Korean study showed that androgen receptors in the gene controlling them were activated best in the presence of IGF-1. IGF-1 is a potent growth factor that works in combination with growth hormone to promote muscle hypertrophy. Intense training can optimize growth hormone and IGF-1 levels, which also assists testosterone metabolism, especially at the receptor level. The study shows that anabolic hormones work together to promote enhancements in muscle growth and strength.
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