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    Home ยป Methadone – Uses, Side Effects, and Withdrawal
    Medications, Drugs & Supplements

    Methadone – Uses, Side Effects, and Withdrawal

    Dr. Laura BennettBy Dr. Laura BennettApril 23, 2026No Comments4 Mins Read
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    methadone

    Methadone is an opiate narcotic analgesic. Methadone has two main functions. It is prescribed to relieve moderate to severe pain in patients when non-narcotic pain relievers do not achieve adequate results. It is also used to prevent withdrawal symptoms and dependence in patients who are addicted to opiate drugs, such as heroin or morphine.

    Methadone for Pain Relief

    When used to treat moderate to severe pain, methadone works by changing the way the nervous system and the brain respond to pain. Methadone is considered an opiate (narcotic) analgesic.

    Methadone is used every four to 12 hours to relieve pain. The prescribing physician will decided on the correct dosage based on the needs of the individual patient. Dosages may be increased or decreased depending on the level of pain relief achieved.

    Methadone should not be stopped without first discussing this with the prescribing doctor. Doctors generally decrease the dosage to avoid any withdrawal symptoms.

    Methadone for Treatment of Narcotic Addiction, Withdrawal, and Dependence

    Methadone has been used for over 30 years to safely and effectively treat narcotic withdrawal and dependence. Heroin or morphine type drugs release an excess of dopamine in the body and cause users to need heroine or the drug of choice to continuously occupy the opioid receptor in the brain. Methadone works by occupying the opioid receptor and is the stabilizer to allow addicts to change their behavior and stop heroin or other opioid drug use by eliminating withdrawal symptoms.

    Methadone suppresses narcotic withdrawal for 24 to 36 hours. It reduces cravings associated with heroin or other opioid drugs and blocks the high and does not provide an euphoric rush. Patients on methadone do not experience extreme highs and lows associated with different heroin levels in the blood stream.

    Methadone withdrawal is slower than heroin withdrawal. Addicts on methadone do not experience the harsh side effects of heroin. Many patients require continuous treatment for several years.

    Methadone treatment programs are highly regulated by the U.S. Food and Drug Administration. Patients on a methadone treatment program for opioid addiction are required to report to methadone clinics and physician offices to obtain doses of methadone.

    Side Effects of Methadone

    Methadone can cause a number of side effects. Any of the following side effects, if severe, should be reported to the prescribing physician:

    • weakness
    • headache
    • nausea or vomiting
    • loss of appetite
    • drowsiness
    • weight gain
    • vision problems
    • mood changes
    • difficulty falling asleep or staying asleep
    • swelling of the hands, arms, feet or legs
    • sweating or flushing
    • stomach pain
    • constipation
    • difficulty urinating
    • dry mouth
    • missed menstrual periods
    • decreased sexual ability or desire

    Patients need to contact their doctor immediately if they experience any seizures, itching, hives, or have a rash.

    Warning Regarding Methadone Usage

    Methadone may cause an irregular heartbeat or slowed breathing, both can be life-threatening. Patients should contact their physician immediately if they experience:

    • difficulty breathing
    • extreme drowsiness
    • shallow or slow breathing
    • fast, slow, pounding, or irregular heartbeat
    • severe dizziness
    • faintness
    • confusion

    The risk of these side effects is greatest when methadone is first used. Doctors may start a patient on a low dose and gradually increase the dose as the body adjusts to the medication.

    Never take more methadone than prescribed. If taking methadone for pain management, pain may return before it is time for the next dose of methadone. Do not take an extra dose. Methadone can build up in the body and cause a life threatening side effect. Talk to the doctor if the pain medication is not lasting long enough between doses.

    Considerations Regarding Methadone Use

    Methadone is an effective treatment for patients in severe pain. It can be used safely and has shown positive results in opioid addicted patients.

    Methadone should be stored in a safe place and never be used by a person that was not prescribed the medication. Keep track of how many tablets or how much solution is left to help determine if any is missing.

    Always keep appointments with doctors, clinics, and laboratories. Physicians will need to check on every patient’s response to methadone. Methadone is not a refillable prescription. Patients will need to see the doctor each time a prescription is needed.

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    Dr. Laura Bennett

    Dr. Laura Bennett is a health writer with a background in biomedical sciences. She focuses on explaining medical conditions, human physiology, and public health topics in a clear, evidence-based, and reader-friendly way.

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