Skip to main content

IGF-1 Activates Androgen Receptor Activity

IGF-1

Testosterone is a highly anabolic hormone that acts by binding with androgen receptors. This signals the cell nucleus to augment the synthesis of new proteins. Until recently, scientists and physicians looked at the role of testosterone in muscle metabolism at a very superficial level. They suppose that a normal blood testosterone level meant that the system was functioning normally and even optimally. Advances in cellular biochemistry showed that the system is much more complicated.

Activation of specific genes and hormone receptor sites are more imperative than circulating levels of hormones and chemical growth factors. Besides, hormones such as testosterone, human growth hormone, and IGF-I must work together to make the optimal effect. A Korean study showed that androgen receptors in the gene controlling them were activated best in the presence of IGF-1. IGF-1 is a potent growth factor that works in combination with growth hormone to promote muscle hypertrophy. Intense training can optimize growth hormone and IGF-1 levels, which also assists testosterone metabolism, especially at the receptor level. The study shows that anabolic hormones work together to promote enhancements in muscle growth and strength.

Popular posts from this blog

Safeguard the Achilles

One of the most painful tendon injuries is Achilles. But there are also ways to avoid these injuries. Here are some of them: You’ll feel a burning and piercing in the tendon above your heel and it can even make a crackling sound when you move it. Any higher up your calf and it’s more likely that you’ve strained or pulled a muscle. Rupturing your Achilles tendon is a exceptionally painful experience and you’ll know when you’ve done it. Your Achilles tendon connects your calf muscles to your heel bone and is made of thousands of individual fibers of collagen. Restricted blood flow to this area slows repair and pain will worsen if you keep training . Four important factors in healing the Achilles are: rest, ice, compression and elevation. If your tendon is harmed take a break from all weight bearing sport (except swimming) for at least 2 weeks. You can recover from mild injury in a couple of weeks but a severe one can take 5 months. In order to prevent Achilles injury in

Diabetes Food Pyramid

This diabetic food pyramid functions in a similar way to the regular food pyramid. One of the main differences is that the diabetic food pyramid focuses on limiting sugar intake . Diabetes is a disease that prohibits people from eating sugar at the same levels that they used to. This does not mean that all diabetics have to avoid sugar like vampires avoid the sun! Some people have mild cases that enable them to eat sugar once in a while. Others have to avoid it at all costs. The diabetic food pyramid is a lifesaver to many people. Just by looking at the pyramid they can tell which foods to eat and which ones not to. It also suggests serving sizes and suggestions for planning whole meals. The diabetic food pyramid has six categories of food groups. At the bottom the main group is grains, starchy vegetables, and beans. The second grouping on the diabetic food pyramid includes vegetables and fruits . The third includes diary products, meats and other sources of protein. At the t

Causes of Easy Bruising: Reasons Why People Bruise Easily

Bruising , a reddish or purple discoloration under the skin, most often results from trauma to the small blood vessels, called capillaries, but can also occur spontaneously. How and Why Bruises Occur Blood leaks out of the capillaries and accumulates under the skin, gradually absorbing over several days. Bruising most often occurs because people run into objects or experience other trauma. Most bruising is easily explained, but frequent bruising that occurs without obvious cause needs prompt investigation, since several serious diseases can cause bruising. In general, women bruise more easily than men. How Aging Increases the Risk of Easy Bruising Bruising increases as people age for several reasons. Skin thins as people age and the capillaries become more fragile. The layer of fat that cushions blood vessels and protects them from injury becomes thinner as well. Older people often take medications and supplements that thin the blood and contribute to easy bruising. Visi